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Cleveland Clinic Journal of Medicine

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Current Issue

01 Jun 2025 (Vol. 92 Issue 6) Table of Contents
Cleveland Clinic Journal of Medicine: 92 (6)

Issue highlights

  • Direct oral anticoagulants: Challenging prescribing scenarios in everyday practice
  • IgA nephropathy: Update on pathogenesis and treatment
  • Severe cutaneous reaction induced by allopurinol

Beyond the Pages Cleveland Clinic Journal of Medicine Podcast

Summaries from Kidney Week 2024

Featured Articles

  • Nitrogen: The unsung hero of vascular physiology
    June 02, 2025
  • Should I start anticoagulation in my patient newly diagnosed with pulmonary hypertension?
    June 02, 2025
  • Allopurinol hypersensitivity is rare, bad, and partially avoidable, but allopurinol can still be...
    June 02, 2025
  • Do I need to treat supine hypertension in my hospitalized patient?
    May 01, 2025
  • Managing right ventricular failure in the setting of pulmonary embolism
    May 01, 2025
  • The gift of lasting immunity
    May 01, 2025
  • Should glucagon-like peptide 1 receptor agonists be withheld during the preoperative period?
    April 01, 2025
  • 2024 ACC/AHA guideline on perioperative cardiovascular management before noncardiac surgery: What’s...
    April 01, 2025
  • Psychedelics in the medical toolbox?
    April 01, 2025
  • Coronary artery bypass grafting: Practice trends and projections
    March 03, 2025
  • All sulfa drugs are not created equal
    March 03, 2025

Latest Articles

  • You have access
    High-output heart failure from arteriovenous dialysis access: A structured approach to diagnosis and management
    Maximilian C. Volk, DO, Bianca Honnekeri, MD, Joanna Ghobrial, MD, Mazen Hanna, MD, Sanjeeb Bhattacharya, MD, Lee Kirksey, MD, J. Emanuel Finet, MD and Heba Wassif, MD, MPH
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 362-371; DOI: https://doi.org/10.3949/ccjm.92a.24114

    Arteriovenous high-output heart failure is likely underdiagnosed because many clinicians are uncertain about when and how to evaluate for it.

  • You have access
    Direct oral anticoagulants: Challenging prescribing scenarios in everyday practice
    CME article
    Syed Bukhari, MD, MHA, Mohamed Ghoweba, MD, Syed Zamrak Khan, MD, Ammar Saati, MD and Marcelo Gomes, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 353-361; DOI: https://doi.org/10.3949/ccjm.92a.24061

    Preapproval trials of direct oral anticoagulants excluded patients with extreme body weight and advanced kidney and liver disease and those who had undergone bariatric surgery. Cautious decision-making in these patients is warranted.

  • You have access
    My adult patient’s hypercholesterolemia is not responding to statins—what’s next?
    Faaiq N. Aslam, MD, Mohamed G. Ibrahim, DO and Razvan Chirila, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 347-351; DOI: https://doi.org/10.3949/ccjm.92a.24117

    Further investigation is needed when patients do not meet their target low-density lipoprotein cholesterol levels with statin therapy alone.

  • You have access
    Nitrogen: The unsung hero of vascular physiology
    Adam J. Brown, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 344-346; DOI: https://doi.org/10.3949/ccjm.92a.24120

    The seventh element on the periodic table—nitrogen—may not come to mind often in day-to-day medical practice, but it is more exciting than you might think.

  • IgA nephropathy: Update on pathogenesis and treatment
    You have access
    IgA nephropathy: Update on pathogenesis and treatment
    Seshma Ramsawak, MD, Scott Cohen, MD, Andrea Linares, DO and Corey Cavanaugh, DO
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 373-383; DOI: https://doi.org/10.3949/ccjm.92a.24105

    Renin-angiotensin-aldosterone system inhibitors or corticosteroids remain the cornerstone of therapy, but new agents targeting the different “hits” in the pathogenesis of IgA nephropathy are being introduced.

  • You have access
    Severe cutaneous reaction induced by allopurinol
    Pietro Bocchi, MD, Lorenza Terroni, MD and Corrado Pattacini, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 331-333; DOI: https://doi.org/10.3949/ccjm.92a.24063

    Three weeks after starting allopurinol for gout, an 86-year-old woman presented with a maculopapular rash and painful blistering and erosions of the oral mucosa.

  • You have access
    Allopurinol hypersensitivity is rare, bad, and partially avoidable, but allopurinol can still be used effectively
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 326-328; DOI: https://doi.org/10.3949/ccjm.92b.06025

    The shadow of the 1984 Hande et al guidelines still hangs over clinical decision-making when managing allopurinol dosing in patients with gout and chronic kidney disease.

  • You have access
    Should I start anticoagulation in my patient newly diagnosed with pulmonary hypertension?
    Tark Abou-Elmagd, MD, MSc, MBBCh and Shraddha Narechania, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 339-343; DOI: https://doi.org/10.3949/ccjm.92a.24083

    The decision hinges on the subtype of pulmonary hypertension the patient has.

  • You have access
    Amoxicillin rash in infectious mononucleosis
    Yasuhiro Kano, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 335-337; DOI: https://doi.org/10.3949/ccjm.92a.24039

    A 23-year-old woman developed a rash on the day she completed a 10-day course of amoxicillin for group A streptococcal infection.

  • You have access
    The gift of lasting immunity
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 263-264; DOI: https://doi.org/10.3949/ccjm.92b.05025

    Measles vaccine–induced immunity, although not necessarily lifelong for all individuals, is quite durable.

View more latest articles
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High-output heart failure from arteriovenous dialysis access: A structured approach to diagnosis and management
My adult patient’s hypercholesterolemia is not responding to statins—what’s next?
Amoxicillin rash in infectious mononucleosis
The beat goes on: Highlights from the new American and European A-fib guidelines
What diagnostic tests should be done after discovering clubbing in a patient without cardiopulmonary symptoms?
Tinea incognito
Prolonged venous filling time and dependent rubor in a patient with peripheral artery disease
Nociplastic pain: A practical guide to chronic pain management in the primary care setting
Sarcoidosis with diffuse purplish erythematous plaques on the hands
Cardiovascular disease in people living with HIV: Risk assessment and management
Heart to heart: Progress in cardiovascular disease prevention for people living with HIV

Cleveland Clinic Journal of Medicine, published by Cleveland Clinic, provides busy clinicians with practical information to promote better patient care.

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