What to do with a broken heart
This issue contains papers discussing noninvasive cardiac testing, the controversy surrounding late thrombosis associated with drug-eluting stents, and how to recognize and repair an atrial septal defect or patent foramen ovale.
B.F. MANDELL

Differentiating bipolar disorder from depression in primary care
When physicians encounter a patient who obviously is depressed, they should not assume that the patient has unipolar depression until they have ruled out bipolar disorder, formerly called "manic-depressive illness."
D.J. MUZINA, E. COLANGELO, J.S. MANNING, and J.R. CALABRESE

Abraham Lincoln and the 'Lincoln sign'
Some believe that a blurry foot in a photograph suggests that our 16th president had aortic regurgitation due to Marfan syndrome.
C. KROEN

Better glycemic control in the hospital: Beneficial and feasible
Professional societies have issued consensus guidelines urging hospitals to tackle hyperglycemia in an organized fashion, and hospitals are taking up the challenge.
S. CLEMENT

Dosage Correction

Choosing the right coronary test
Technical advances have substantially improved the clinician's ability to find and describe coronary disease. They also pose a bewildering array of choices.
M.S. LAUER

What is the best test for a patient with classic angina?
In patients with a normal resting electrocardiogram and no prior revascularization, a regular exercise stress test without imaging should suffice. However, no randomized trials have been done to determine if this strategy leads to better outcomes than empiric therapy does.
M.S. LAUER

Understanding and minimizing late thrombosis in drug-eluting stents
Though late stent thrombosis is rare, the risk is real and it is greater with drug-eluting stents than with bare metal stents.
M.G. RABBAT, A.A. BAVRY, D.L. BHATT, and S.G. ELLIS

Correction

When and how to fix a 'hole in the heart':
Approach to ASD and PFO
While correcting some abnormalities of the atrial septum is beneficial, most other defects warrant correction only under very specific circumstances.
R.A. KRASUSKI

Which ovarian masses need intervention?
Ovarian cancer is deadly if not detected early, but it is only one of many causes of pelvic masses, which are common.
W.C. McBEE JR, P.F. ESCOBAR, and T. FALCONE

Clinical factors predict severe community-acquired pneumonia in adults

Higher hemoglobin target with epoetin alfa is harmful in chronic kidney disease

2006 Reviewers