The angiotensin story continues: ARBs in heart failure
Considering the gravity of the problem of heart failure, it makes sense to have as many alternative pathways to success as we can find.
J.D. CLOUGH

It's what's inside the white coat that counts
Welcoming the first class of the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.
P.M. HALL

Lessons from the PROVE-IT trial. Higher dose of potent statin better for high-risk patients
Patients with acute coronary syndromes should receive aggressive lipid-lowering therapy with a statin in high doses. Goal low-density lipoprotein levels may need to be lower.
K.K. KHUSH and D. WATERS

Cancer pain: How to measure the fifth vital sign
To control pain effectively in cancer patients, we must assess it regularly and consistently.
M.P. DAVIS and D. WALSH

Acute leukemia with a very high leukocyte count: Confronting a medical emergency
From 5% to 30% of adult patients with acute leukemias present with hyperleukocytosis and leukostasis. Prompt action is needed.
N.S. MAJHAIL and A.E. LICHTIN

Evaluation of hyponatremia: A little physiology goes a long way
A careful and logical approach can promptly reveal the causative factor or factors in nearly all cases.
B.J. FREDA, M.B. DAVIDSON, and P.M. HALL

A 76-year-old woman with erratic anticoagulation
A patient previously controlled on warfarin now has bleeding and an INR of 7. What has changed?
E.P. LESHO, L. SAULLO, and S. UDVARI-NAGI

Nonalcoholic fatty liver disease and the epidemic of obesity
Nonalcoholic fatty liver disease, unknown only 2 decades ago, is now ubiquitous, especially among the obese.
R. COLLANTES, J.P. ONG, and Z.M. YOUNOSSI

Angiotensin-receptor blockers in heart failure: Evidence from the CHARM trial
The ARB candesartan was not only a good alternative to an ACE inhibitor, it was beneficial when added to a regimen that already included an ACE inhibitor and a beta-blocker.
S. BHAKTA and M.E. DUNLAP

And an ARB makes nine: Polypharmacy in patients with heart failure
Based on strong evidence, a patient with advanced ischemic cardiomyopathy should be taking nine medications. But it is difficult not to worry about polypharmacy.
J. STEHLIK and D.O. TAYLOR

Carotid endarterectomy prevents stroke in asymptomatic patients

Hypertension follow-up every 6 months is as good as every 3 months

Limited data on benefits of dietary supplements for weight loss

Open hernia repair better than laparoscopic

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