The Vioxx withdrawal: Latest in the COX-2 controversies
Discussion of the COX-2 inhibitors has been emotionally polarized every step of the way, and it's not over. Two other COX-2 drugs are still available, and much money is at stake.
B.F. MANDELL

A world without Vioxx: To COX-2 or not to COX-2?
Are all selective COX-2 inhibitors associated with an increased risk for thromboembolic cardiovascular events? And what should we tell patients?
L.S. SIMON and V. STRAND

Benign prostatic hyperplasia: Now we can begin to tailor treatment
The management of benign prostatic hyperplasia has improved considerably in recent years. A review of medications, surgery, and new minimally invasive procedures.
C.K. GJERTSON, K. WALMSLEY, and S.A. KAPLAN

Understanding valvular heart disease in patients with systemic autoimmune diseases
Specific systemic autoimmune diseases are associated with distinct valvular heart disorders. Earlier detection and management may prevent some morbidity and mortality.
K. MAKSIMOWICZ-McKINNON and B.F. MANDELL

Radiologic imaging in rhinosinusitis
Imaging may be necessary for rhinosinusitis that is refractory, chronic, recurrent, or complicated.
P.S. BATRA

A practical program for preventing delirium in hospitalized older patients
Delirium in hospitalized elderly patients is common, often unrecognized, and can lead to serious complications. A systematic program can improve the rate of recognition and decrease the rate of incidence.
S.K. INOUYE, MD

Safe use of opioids in chronic noncancer pain
Many physicians needlessly avoid prescribing opioid analgesics for chronic pain because of misconceptions about efficacy, adverse effects, abuse, and addiction potential.
T.E. DEWS and N. MEKHAIL

A guide to informed consent for clinician-investigators
Informed consent is a process, not a form. It is a legal and ethical safeguard to ensure that subjects enter studies voluntarily and fully informed.
K.A. BRAMSTEDT

Three percent of TIA patients have a stroke within 30 days

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